Related Experiment Video
Updated: Oct 12, 2025
Author Spotlight: Enhancing Skin Model Diversity with Cost-Effective 3D Cellular Models
Published on: October 20, 2023
Approach to differentiate between hyaluronic acid skin quality boosters and fillers based on their physicochemical
Linda Kleine-Börger1, Robert Meyer2, Alexander Kalies3
1Cosmetic Science, Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.
Background:
The clinical indications, applications, and effect of the injectable hyaluronic acid range skin quality boosters (SQBs) are different than those of filler products. Material properties are increasingly being discussed for differentiation and in connection with clinical effects and esthetic indications.
Aims:
The aim of this study is to evaluate whether SQB products can be differentiated from filler products by their physicochemical material properties.
Material And Methods:
Physicochemical properties (extrusion force, swelling degree, rheology, and cohesivity) of two SQBs (BELR , JUVVE ) were compared with those of fillers (BELB , JUVVT ) using the same manufacturing technology.
Results:
Cohesivity was almost equal for SQBs and fillers. Few statistically significant differences in physicochemical properties were found. Properties of SQBs differed from fillers mainly in their delta of rheological properties and extrusion force.
Conclusion:
In this study, physicochemical differences between SQB and filler were determined and described, supporting the presence of two categories and their different clinical indications and applications.
Related Concept Videos
01:23Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
01:17Connective Tissue Fibers and Ground Substance