Related Experiment Video
Updated: Oct 12, 2025

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
Isoflurane as an Accurate Negative Mode Calibrant for Ion Mobility Spectrometry
Brian C Hauck1, Charles S Harden1, Vincent M McHugh2
1Science and Technology Corporation, 111C Bata Boulevard, Belcamp, Maryland 21017, United States.
Isoflurane (IsoF) shows promise as a negative ion mode calibrant for ion mobility spectrometry (IMS). Its reduced ion mobility (K0) values were accurately measured under various conditions, supporting its suitability for IMS calibration.
Area of Science:
- Analytical Chemistry
- Physical Chemistry
Background:
- Ion mobility spectrometry (IMS) requires accurate calibrant compounds for device calibration.
- Limited research exists for negative ion mode calibrants compared to positive ion mode.
Purpose of the Study:
- To investigate isoflurane (IsoF) as a potential negative ion mode calibrant for IMS.
- To accurately measure reduced ion mobility (K0) values for IsoF product ions.
Main Methods:
- Measured K0 values for IsoF product ions across varying instrumental parameters.
- Utilized two distinct IMS instrumentation modes.
- Varied drift gas temperature, water concentration, and dopant concentration.
Main Results:
- Accurately determined K0 values for IsoF product ions under multiple conditions.
- Evaluated the impact of instrumental parameters on IsoF K0 values.
- Demonstrated the influence of temperature, water, and dopant concentrations.
Conclusions:
- Isoflurane (IsoF) is a suitable candidate for negative ion mode IMS calibration.
- The measured K0 values provide essential data for calibrating IMS devices.
- Further validation supports IsoF's role in enhancing IMS accuracy for chemical detection.
More Related Videos
04:56In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
08:56Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
Published on: November 22, 2024
Related Concept Videos
Chemical Ionization (CI) Mass Spectrometry
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences
High-Resolution Mass Spectrometry (HRMS)
Electrospray Ionization (ESI) Mass Spectrometry
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
Mass Spectrum: Interpretation
To...
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview