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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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Polymer Translocation Time.

Yuyuan Lu1,2, Zhenhua Wang1, Lijia An1,2

  • 1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China.

The Journal of Physical Chemistry Letters
|November 22, 2021
PubMed
Summary
This summary is machine-generated.

This study compares how linear and ring polymers move through channels using force or flow. Differences in polymer translocation time arise from how monomers crowd, impacting applications like molecular sequencing.

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Area of Science:

  • Polymer Physics
  • Soft Matter Physics
  • Computational Biophysics

Background:

  • Polymer translocation is crucial for biological processes and nanotechnology.
  • Understanding translocation dynamics aids in developing applications like molecular sequencing and filtration.
  • Previous studies often focused on single translocation mechanisms, leaving comparative analyses incomplete.

Purpose of the Study:

  • To investigate and compare force-induced versus flow-induced polymer translocation dynamics.
  • To analyze the translocation time scaling for linear and ring polymers under different driving forces.
  • To elucidate the molecular mechanisms governing these translocation processes.

Main Methods:

  • Utilized a hybrid approach combining multiparticle collision dynamics (MPCD) and molecular dynamics (MD) simulations.
  • Characterized polymer translocation time (τ*) using scaling relations with driving force (f or J) and polymer length (N).
  • Analyzed monomer crowding effects and flow patterns influencing translocation.

Main Results:

  • Translocation time scaling exponents (α) were found to be approximately 1.0 for long polymer chains in both force- and flow-induced scenarios.
  • Distinct monomer crowding effects, influenced by external flow patterns, were identified as the cause for differences between force- and flow-induced translocations.
  • Derived general relations for polymer translocation time showed good agreement with simulation data.

Conclusions:

  • The study provides detailed molecular insights into the distinct mechanisms of force- and flow-induced polymer translocation.
  • Findings clarify the role of monomer crowding and external flow in modulating translocation dynamics.
  • Results offer valuable guidance for optimizing polymer translocation in applications such as molecular sequencing and ultrafiltration.