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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Cortical mechanisms in migraine.

Wei Dai^1,2, Ren-Hao Liu³, Enchao Qiu¹

¹Department of Neurology, Chinese PLA General Hospital, Beijing, China.

|November 22, 2021

Summary

Migraine mechanisms remain unclear, but the cerebral cortex plays a key role. Long-term synaptic plasticity in the cortex may encode migraine attacks.

Keywords:

cerebral cortex cortical spreading depression long-term potentiation migraine pathophysiology

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Area of Science:

Neuroscience
Neurology
Cerebral Cortex Research

Background:

Migraine is a prevalent neurological disorder with poorly understood mechanisms.
The cerebral cortex is implicated in migraine attack initiation, propagation, termination, and interictal phases.

Purpose of the Study:

To review current literature on the cerebral cortex's role in migraine pathophysiology.
To provide an overview of basic cortical structure and function in relation to migraine.

Main Methods:

Literature review of neuroimaging studies (structural, functional, biochemical).
Analysis of research on migraine-related genes.
Examination of theories linking cortical mechanisms to migraine.

Main Results:

The cerebral cortex is central to migraine pathophysiology.
Neuroimaging and genetic studies highlight cortical involvement.
Synaptic plasticity is proposed as a key mechanism.

Conclusions:

Understanding cortical mechanisms in migraine is crucial for developing new treatments.
Long-term synaptic plasticity in the cortex may encode migraine.