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Emerging nanotechnology based combination therapies of taxanes for multiple drug-resistant cancers

Roshan Katekar1,2, Pragati Singh1, Richa Garg1,2

  • 1Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, India.

Pharmaceutical Development and Technology
|November 22, 2021
PubMed

Insights

Combination therapies and advanced nanoformulations show promise in overcoming multiple drug resistance (MDR) to taxane anticancer drugs. This approach aims to improve the clinical efficacy of treatments like docetaxel and paclitaxel.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Multiple drug resistance (MDR) significantly limits the effectiveness of taxane-based chemotherapy (docetaxel, paclitaxel, cabazitaxel).
  • Drug efflux transporters are a primary mechanism driving MDR, impeding the clinical success of these vital anticancer agents.
  • Current pharmaceutical formulations face challenges in overcoming MDR, necessitating innovative therapeutic strategies.

Purpose of the Study:

  • To review the current understanding of MDR in the context of taxane chemotherapy.
  • To explore the potential of combination therapies and advanced nanoformulations to reverse taxane resistance.
  • To highlight the need for polypharmacology and sophisticated nano-delivery systems for improved cancer treatment.

Main Methods:

  • Literature review of existing research on MDR, taxane drugs, and nanoformulations.
  • Analysis of challenges associated with current taxane pharmaceutical products.
  • Examination of combination therapy strategies and nano-delivery systems for taxanes.

Main Results:

  • Combination therapies offer a promising strategy to combat MDR, moving beyond the 'one drug-one target' paradigm.
  • Various nanoformulations (liposomes, micelles, nanoparticles) have been explored for taxane delivery to overcome resistance.
  • There is a gap in the literature concerning polypharmacology and advanced nanoformulations specifically targeting MDR.

Conclusions:

  • Advanced nanoformulations and combination therapies represent a critical frontier in overcoming MDR to taxanes.
  • Further research into polypharmacology and sophisticated nano-delivery systems is essential for enhancing taxane-based cancer treatment efficacy.
  • These strategies hold significant potential for improving patient outcomes in challenging cancer cases.
Keywords:
Combination therapymultiple drug resistancenano deliverytaxanes

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