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Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

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Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale.

Yi Yuan^1,2,3, Ni He^1,2,3, Liya Dong^1,2,3

¹School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.

|November 22, 2021

Summary

This summary is machine-generated.

Shellac, a natural resin, offers versatile and pH-responsive properties for advanced drug delivery systems. Its unique characteristics enable effective encapsulation and targeted release of active substances, particularly for oral administration.

Keywords:

colonic targeting delivery system encapsulation macroscale nanoscale oral administration pH-responsive shellac

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Area of Science:

Pharmaceutical Sciences
Materials Science
Biotechnology

Background:

Delivery systems are vital for enhancing active substance efficacy but often require complex processing.
Easily processable raw materials for diverse delivery systems are increasingly sought.
Shellac, a unique animal-derived resin, is recognized for its pharmaceutical applications.

Purpose of the Study:

To review the advantages of shellac in developing drug delivery systems.
To comprehensively introduce multiscale shellac-based delivery systems.
To analyze current trends, limitations, and future prospects in shellac delivery system development.

Main Methods:

Review of existing literature on shellac-based delivery systems.
Categorization of shellac delivery systems by scale (macro to nano).
Analysis of shellac's properties: pH responsiveness, biocompatibility, degradability, and encapsulation efficiency.

Main Results:

Shellac exhibits superior encapsulation of hydrophobic active substances compared to other natural polymers.
Shellac-based systems facilitate co-delivery of hydrophilic and hydrophobic substances.
Shellac delivery systems are effective for targeted oral administration, protecting payloads from gastric conditions.

Conclusions:

Shellac offers significant advantages for designing advanced drug delivery systems.
A wide range of shellac-based systems, from macro to nanoscale, are available for various applications.
Further research into shellac delivery systems holds promise for improved therapeutic outcomes.