Prostaglandin synthesis and response to alcoholism treatment

Serum prostaglandin F2 (PGF2) was assayed in 27 alcoholic patients and in 18 control subjects. No significant difference was observed in mean basal PGF2 titers of patients and controls. However, patients who completed four months of alcoholism treatment had a mean titer that was significantly higher than that of treatment dropouts. Patients who maintained continuous abstinence for 2 years following treatment had a mean titer that was significantly higher than that of patients who returned to pre-treatment drinking levels.