Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

9.8K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
9.8K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

7.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.7K
Vascular Spasm01:16

Vascular Spasm

2.4K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharyngeal Microenvironment Associated with Human Rhinovirus Infection in Children: Insights from Metatranscriptomic Sequencing.

NPJ biofilms and microbiomes·2026
Same author

Interpretable Deep Learning Radiomics for Differentiating Pleomorphic Adenoma and Warthin Tumor.

In vivo (Athens, Greece)·2026
Same author

Systematic review of self-management practices for vaginal irrigation among cervical cancer patients undergoing radiotherapy.

Frontiers in oncology·2026
Same author

Downregulation of Nrf2 and upregulation of TXNIP/NLRP3 signaling Induce postoperative cognitive dysfunction via oxidative stress and pyroptosis in the hippocampus.

Neuroscience·2026
Same author

Phenotypic and genomic features of virulent mecA-carrying Staphylococcus hyicus isolated from a pig farm with fatal exudative epidermitis.

BMC veterinary research·2026
Same author

Design and therapeutic landscape of copper ionophores: From coordination chemistry to cuproptosis modulation.

Bioorganic & medicinal chemistry·2026

Related Experiment Video

Updated: Oct 12, 2025

A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

10.9K

Jet-Induced Tissue Disruption for Blood Release.

Jiali Xu, James W McKeage, Bryan P Ruddy

    IEEE Transactions on Bio-Medical Engineering
    |November 22, 2021
    PubMed
    Summary

    Needle-free jet injection, a novel blood collection method, shows potential for improved capillary blood release compared to lancet pricks. Slot-shaped jets cause less tissue disruption and smaller wound volumes than circular jets.

    More Related Videos

    Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
    09:03

    Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model

    Published on: March 10, 2023

    2.2K
    Author Spotlight: Revealing Platelet Dynamics Through Advances in Structural Hematology
    05:41

    Author Spotlight: Revealing Platelet Dynamics Through Advances in Structural Hematology

    Published on: May 24, 2024

    414

    Related Experiment Videos

    Last Updated: Oct 12, 2025

    A Novel In Vitro Model of Blast Traumatic Brain Injury
    08:59

    A Novel In Vitro Model of Blast Traumatic Brain Injury

    Published on: December 21, 2018

    10.9K
    Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
    09:03

    Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model

    Published on: March 10, 2023

    2.2K
    Author Spotlight: Revealing Platelet Dynamics Through Advances in Structural Hematology
    05:41

    Author Spotlight: Revealing Platelet Dynamics Through Advances in Structural Hematology

    Published on: May 24, 2024

    414

    Area of Science:

    • Biomedical Engineering
    • Dermatology
    • Medical Device Technology

    Background:

    • Needle-free jet injection is an established drug delivery method.
    • Recent applications explore its use for capillary blood sampling, potentially replacing lancet devices.
    • Understanding tissue interaction is key for optimizing this technology.

    Purpose of the Study:

    • To investigate and compare the wound geometry and tissue disruption caused by shallow jet injections using circular and slot-shaped jets.
    • To evaluate the potential of jet injection for capillary blood release.

    Main Methods:

    • Histological analysis of porcine skin samples.
    • Comparison of tissue disruption, vascular endothelium damage, penetration depth, and wound volume between lancet-pricking, circular jet injection, and slot-shaped jet injection.

    Main Results:

    • Slot-shaped jets caused greater disruption of vascular endothelium compared to circular jets.
    • Slot-shaped jets achieved this at shallower penetration depths and smaller wound volumes.
    • Shallow jet injections demonstrated potential for increased capillary blood release compared to lancet pricks.

    Conclusions:

    • Jet injection technology, particularly with slot-shaped jets, shows promise for capillary blood sampling.
    • This could offer an alternative to lancet devices, with potential applications in diabetes management for blood glucose monitoring and insulin delivery.