Related Experiment Video
Updated: Oct 12, 2025
08:59
A Novel In Vitro Model of Blast Traumatic Brain Injury
Published on: December 21, 2018
10.9K
Jet-Induced Tissue Disruption for Blood Release.
IEEE Transactions on Bio-Medical Engineering
|November 22, 2021
Summary
Needle-free jet injection, a novel blood collection method, shows potential for improved capillary blood release compared to lancet pricks. Slot-shaped jets cause less tissue disruption and smaller wound volumes than circular jets.
Area of Science:
- Biomedical Engineering
- Dermatology
- Medical Device Technology
Background:
- Needle-free jet injection is an established drug delivery method.
- Recent applications explore its use for capillary blood sampling, potentially replacing lancet devices.
- Understanding tissue interaction is key for optimizing this technology.
Purpose of the Study:
- To investigate and compare the wound geometry and tissue disruption caused by shallow jet injections using circular and slot-shaped jets.
- To evaluate the potential of jet injection for capillary blood release.
Main Methods:
- Histological analysis of porcine skin samples.
- Comparison of tissue disruption, vascular endothelium damage, penetration depth, and wound volume between lancet-pricking, circular jet injection, and slot-shaped jet injection.
Main Results:
- Slot-shaped jets caused greater disruption of vascular endothelium compared to circular jets.
- Slot-shaped jets achieved this at shallower penetration depths and smaller wound volumes.
- Shallow jet injections demonstrated potential for increased capillary blood release compared to lancet pricks.
Conclusions:
- Jet injection technology, particularly with slot-shaped jets, shows promise for capillary blood sampling.
- This could offer an alternative to lancet devices, with potential applications in diabetes management for blood glucose monitoring and insulin delivery.
Related Concept Videos
01:05Introduction to Hemostasis
9.8K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
9.8K
01:22Formation of the Platelet Plug
7.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.7K
01:16Vascular Spasm
2.4K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
2.4K