Midazolam-Induced Hiccups Reversed by Flumazenil: A Case Report
Related Experiment Video
Updated: Nov 3, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Prashant N Rao1, Christopher L Wu, Jacques T YaDeau
1From the Department of Anesthesiology, Critical Care, and Pain Management, Hospital for Special Surgery, New York, New York.
Abstract:
Hiccups are a common phenomenon experienced by many people and are usually short-lived with spontaneous resolution of symptoms. Certain anesthetic medications have been associated with the development of hiccups, though the underlying pathophysiology and reflex arcs remain poorly understood. We describe a patient who developed hiccups lasting 9 days following an orthopedic surgery and again developed hiccups during a subsequent surgery after only having received midazolam; flumazenil administration led to sustained cessation of his hiccup symptoms immediately.
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