Related Experiment Videos
Renal effects of nadolol in cirrhosis
A Gatta1, D Sacerdoti, C Merkel
1Department of Clinical Medicine, University of Padua, Italy.
Insights
Nadolol treatment in cirrhotics significantly improved renal function and hemodynamics by increasing cardiac output delivery to kidneys. It also suppressed the renin-angiotensin-aldosterone system and increased prostaglandin E2 excretion.
Area of Science:
- Nephrology
- Cardiology
- Pharmacology
Background:
- Cirrhosis often leads to altered renal hemodynamics and function.
- Beta-blockers like nadolol are used in cirrhosis management, but their renal effects require clarification.
Purpose of the Study:
- To investigate the impact of nadolol on renal hemodynamics, function, and the renin-angiotensin-aldosterone system in cirrhotic patients.
Main Methods:
- Eighteen cirrhotic patients were treated with nadolol for one month.
- Measurements included cardiac output, arterial pressure, renal plasma flow, glomerular filtration rate, and urinary PGE2 excretion.
Main Results:
- Nadolol decreased cardiac output by 25% but increased glomerular filtration rate and renal blood flow proportion.
- The renin-angiotensin-aldosterone system was suppressed, and urinary PGE2 excretion showed a slight increase.
Conclusions:
- Nadolol improves renal hemodynamics and function in cirrhotics, independent of arterial pressure changes.
- Nadolol's effects on renal function are not directly correlated with its impact on the renin-angiotensin-aldosterone system or prostaglandin production.
Abstract:
The effects of nadolol on renal haemodynamics and function, and on the renin-angiotensin-aldosterone system and on renal prostaglandin production were studied in eighteen cirrhotics. After 1 month of treatment, nadolol had significantly decreased cardiac output by 25% without affecting arterial pressure, renal plasma flow or renal vascular resistance. Glomerular filtration rate, filtration fraction and the proportion of the cardiac output delivered to the kidneys were significantly increased. The renin-angiotensin-aldosterone system was suppressed and urinary PGE2 excretion was slightly increased. The latter effects were not correlated with those on renal haemodynamics and function.