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Updated: Oct 12, 2025

Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons
Published on: September 7, 2017
The form, function, and evolutionary significance of neural aromatization
Barney A Schlinger1, Luke Remage-Healey2, Colin J Saldanha3
1Deparments of Integrative Biology and Physiology & Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, United States.
Abstract:
Songbirds have emerged as exceptional research subjects for helping us appreciate and understand estrogen synthesis and function in brain. In the context of recognizing the vertebrate-wide importance of brain aromatase expression, in this review we highlight where we believe studies of songbirds have provided clarification and conceptual insight. We follow by focusing on more recent studies of aromatase and neuroestrogen function in the hippocampus and the pallial auditory processing region NCM of songbirds. With perspectives drawn from this body of work, we speculate that the evolution of enhanced neural estrogen signaling, including in the mediation of social behaviors, may have given songbirds the resilience to radiate into one of the most successful vertebrate groups on the planet.
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