Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Confocal Fluorescence Microscopy

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cuscuta chinensis Lam. extract alleviates ovariectomy-induced osteoporosis by inhibiting VCP-mediated METTL3 protein degradation.

Journal of molecular histology·2026

Same author

A dual-pronged strategy: multi-bioactive nanoplatform synergizes ROS antidote and iron stabilization to protect against liver ischemia-reperfusion injury.

Journal of nanobiotechnology·2026

Same author

A natural remedy: Kidney-targeting nanoplatform for photoacoustic imaging-guided three-in-one theranostics of rhabdomyolysis-induced acute kidney injury.

Materials today. Bio·2026

Same author

Towards a single-laser-diode-pumped 15-GHz Ti:sapphire astrocomb.

Optics express·2026

Same author

Comb-mode sweeping in a 650 nm-1030 nm astrocomb.

Optics express·2026

Same author

Hyaluronic acid engineered melanin-MOF nanoreactor synergistically remodeling redox and immune homeostasis for targeted acute lung injury therapy.

Materials today. Bio·2026

Same journal

Denoising algorithm of Φ-OTDR systems based on adaptive fractional wavelet transform denoising.

Optics express·2026

Same journal

Millisecond photon-to-photon latency and high-speed volumetric projection system for optogenetics.

Optics express·2026

Same journal

Polarization-encoded coaxial structured light for high-precision 3D surface profilometry.

Optics express·2026

Same journal

Discrete freeform optical design based on collaborative optimization of point cloud and local normals.

Optics express·2026

Same journal

Ultrafast ghost imaging with 25 GHz speckle switching and wavelength-division multiplexing.

Optics express·2026

Same journal

Atomic vapor cells fabricated by femtosecond laser welding of standard-optical-quality glass.

Optics express·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 12, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

Two-photon dual-comb LiDAR.

Hollie Wright, Jinghua Sun, David McKendrick

|November 23, 2021

Summary

This summary is machine-generated.

This study introduces a novel dual-comb laser ranging technique using cross-polarized combs and two-photon detection. This method achieves carrier-phase-insensitive cross-correlations, enabling high-precision distance metrology with enhanced sampling rates.

More Related Videos

In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy

In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy

Published on: December 20, 2021

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

Related Experiment Videos

Last Updated: Oct 12, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy

In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy

Published on: December 20, 2021

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

Area of Science:

Optics and Photonics
Laser Metrology
Quantum Optics

Background:

Conventional dual-comb laser ranging requires stable femtosecond lasers and faces limitations in sampling rates due to radio-frequency aliasing.
Existing methods necessitate long-term carrier-envelope offset frequency stability, posing technical challenges.

Purpose of the Study:

To develop a carrier-phase-insensitive dual-comb laser ranging technique with significantly increased sampling rates.
To implement a real-time, continuous LiDAR-like distance metrology system with sub-100 nm precision.
To reduce the data burden associated with conventional dual-comb acquisition systems.

Main Methods:

Utilizing cross-polarized dual combs and two-photon detection to achieve carrier-phase-insensitive cross-correlations.
Employing a digitizer-based acquisition system for recording cross-correlations at sampling rates up to 12x the conventional limit.
Integrating a microcontroller as a high-precision stopwatch to record time intervals between two-photon cross-correlation pulses, eliminating the need for high data throughput.

Main Results:

Demonstrated carrier-phase-insensitive cross-correlations at sampling rates significantly exceeding conventional dual-comb aliasing limits.
Achieved sub-100 nm precision in distance metrology using the developed ranging technique.
Successfully implemented a real-time, continuous LiDAR-like distance measurement system with dynamic acquisition capabilities for unlimited periods.

Conclusions:

The novel dual-comb laser ranging method overcomes limitations of conventional techniques by enhancing sampling rates and reducing data requirements.
This approach offers a robust and efficient solution for high-precision distance metrology, suitable for real-time applications.
The system provides a pathway towards advanced LiDAR-like technologies with unprecedented precision and continuous operation.