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Updated: Jun 16, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Quantitative Electroencephalography for Early Detection of Elevated Intracranial Pressure in Critically Ill Children:

Arnold J Sansevere1,2, Melissa L DiBacco1,2, Phillip L Pearl1,2

  • 1Division of Epilepsy and Neurophysiology, Boston Children's Hospital, Boston, MA, USA.

Journal of Child Neurology
|November 23, 2021
PubMed

Insights

Quantitative EEG suppression ratio increases precede imaging findings of increased intracranial pressure in children. This early indicator may guide interventions for elevated intracranial pressure, potentially reducing severe outcomes.

Area of Science:

  • Pediatric Neurology
  • Neurophysiology

Background:

  • Increased intracranial pressure (ICP) is a critical condition in children, often leading to significant morbidity and mortality.
  • Continuous electroencephalography (EEG) monitoring is vital for assessing neurological status in critically ill children.

Purpose of the Study:

  • To evaluate the utility of the quantitative EEG suppression ratio as an early marker for increased intracranial pressure in pediatric patients.
  • To compare the timing of suppression ratio changes with neuroimaging and clinical examination findings indicative of elevated ICP.

Main Methods:

  • A retrospective review of continuous EEG data was conducted for pediatric patients with confirmed increased intracranial pressure.
  • The time of the initial rise in the EEG suppression ratio was compared to the time of the first neuroimaging or clinical evidence of elevated ICP.

Main Results:

  • The study included 13 pediatric patients with a median age of 3.1 years.
  • A rise in the suppression ratio was observed preceding neuroimaging or examination findings of increased ICP by a median of 3.12 hours.

Conclusions:

  • An increased EEG suppression ratio serves as an early indicator of elevated intracranial pressure in children.
  • Targeting the suppression ratio with ICP-lowering therapies could potentially mitigate adverse outcomes associated with increased intracranial pressure.
Abstract

Keywords:
continuous electroencephalographyincreased intracranial pressurepediatric intensive care unitquantitative electroencephalography

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