Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

29
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
29
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.9K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.9K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

23
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
23
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

22
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
22
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

35
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
35
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

21
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
21

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Limb-Sparing Reconstruction for Chronic Non-Bacterial Osteomyelitis of the Toe in a Pediatric Athlete: A Case Report.

Reports (MDPI)·2026
Same author

Field effects in penile squamous cell carcinoma: Insights from Wnt-related protein expression.

Clinical and experimental dermatology·2026
Same author

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines.

Molecular oncology·2025
Same author

An Ex Vivo Evaluation of Air Intrusion Into Pulsed Field Ablation Sheaths During Ablation and Mapping Catheter Insertion.

Journal of cardiovascular electrophysiology·2025
Same author

Does propranolol have a role in cancer treatment? A systematic review of the epidemiological and clinical trial literature on beta-blockers.

Journal of cancer research and clinical oncology·2025
Same author

Super-Resolution Microscopy Reveals Alterations in Clathrin Structure in Human Cancer Tissue.

The American journal of pathology·2025

Related Experiment Video

Updated: Oct 12, 2025

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
10:31

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion

Published on: September 25, 2014

13.6K

Pediatric Sports Injuries.

Joshua Strassberg1, Aamir Ahmed2

  • 1The Pediatric Orthopedic Center, 218 Ridgedale Avenue, Suite 101, Cedar Knolls, NJ 07927, USA.

Clinics in Podiatric Medicine and Surgery
|November 23, 2021
PubMed
Summary

Athletes often sustain sports injuries in the leg, foot, and ankle due to insufficient rest. This article reviews common injuries and their recovery, covering both conservative and surgical treatments for athletes.

Keywords:
Chronic exertional compartment syndromeExertional painForefoot painLeg painRepetitive stressSesamoiditisStress fracturesTurf toe

More Related Videos

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
07:02

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Published on: January 12, 2011

16.0K
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

3.4K

Related Experiment Videos

Last Updated: Oct 12, 2025

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
10:31

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion

Published on: September 25, 2014

13.6K
An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
07:02

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Published on: January 12, 2011

16.0K
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

3.4K

Area of Science:

  • Sports Medicine
  • Orthopedics
  • Podiatry

Background:

  • Increased participation in year-round multi-sport athletics.
  • Athletes frequently neglect proper rest, increasing susceptibility to stress-related injuries.
  • Foot and ankle injuries are prevalent in sports, stemming from chronic stress or trauma.

Purpose of the Study:

  • To discuss common sports-related injuries affecting the leg, foot, and ankle.
  • To outline the recovery processes for these athletic injuries.
  • To highlight the importance of rest in injury prevention for athletes.

Main Methods:

  • Review of common sports injuries in the leg, foot, and ankle.
  • Discussion of non-traumatic (repetitive stress) and traumatic injury mechanisms.
  • Overview of conservative and operative management strategies.

Main Results:

  • Most sports-related foot and ankle injuries are managed successfully with conservative treatment.
  • Some athletes benefit more from operative management for their injuries.
  • Understanding injury mechanisms aids in appropriate treatment selection.

Conclusions:

  • Proper rest is crucial for athletes to prevent stress-related injuries.
  • A range of management options exist for leg, foot, and ankle sports injuries.
  • Many athletes can return to play after appropriate treatment for their injuries.