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Updated: Oct 12, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Modulating neuroinflammation in COVID-19 patients with obsessive-compulsive disorder
Vera Nezgovorova1, Casara Jean Ferretti1, Stefano Pallanti2
1Autism and Obsessive-Compulsive Spectrum Program, Psychiatry Research Institute of Montefiore-Einstein, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Abstract:
Exacerbation of symptoms of obsessive-compulsive disorder (OCD) during COVID-19 or new onset of the OCD symptoms resulting from COVID-19 infection is an understudied area of research. It is possible that increased proinflammatory immune status is associated with the onset of obsessive-compulsive symptoms in patients with COVID-19 and that targeted anti-inflammatory treatments for COVID-19 infection can mitigate the new onset of Obsessive-Compulsive (OC) spectrum symptoms. In this review, we cover OCD pathogenesis as related to COVID-19, summarize the impact of cytokines on behavior, and suggest that anti-cytokine treatments can help mitigate post-COVID-19 and new onset of the OC symptoms.
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