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Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
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Metabolic Regulation of Inflammation and Its Resolution: Current Status, Clinical Needs, Challenges, and
Pushpa Tandon1, Natalie D Abrams2, Danielle M Carrick2
1National Cancer Institute, National Institutes of Health, Rockville, MD; tandonp@mail.nih.gov.
Journal of Immunology (Baltimore, Md. : 1950)
|November 23, 2021
Summary
The study explores immunometabolism, the link between metabolism and immune responses. Understanding this connection is key for developing new strategies against diseases like cancer.
Area of Science:
- Immunology
- Metabolism
- Biochemistry
Background:
- Metabolism and inflammation are distinct survival processes.
- Both processes restore homeostasis under stress.
- Their interplay, immunometabolism, impacts health and disease.
Purpose of the Study:
- To discuss innovative approaches in immunometabolism.
- To identify challenges and opportunities in the field.
- To explore harnessing immunometabolism for disease prevention and therapy.
Main Methods:
- Trans-NIH workshop.
- Brought together basic scientists, technology developers, and clinicians.
Main Results:
- Discussion on state-of-the-art approaches.
- Identification of key challenges and opportunities.
Conclusions:
- Understanding immunometabolism is critical for novel therapeutic strategies.
- Harnessing immunometabolism can modulate inflammation and its resolution.
- Further research is needed to develop preventative and therapeutic tools for diseases, including cancer.
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