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Preparation of 1° Amines: Gabriel Synthesis

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...

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Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

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Medal for metal-free methods

Katherine Geogheghan¹

¹Nature Chemistry, . katherine.geogheghan@nature.com.

Nature Chemistry

|November 23, 2021

Summary

No abstract available in PubMed .

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