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The regenerating protein 3A: a crucial molecular with dual roles in cancer

Liying Wang1,2, Yanchun Quan3,4,5, Yanxi Zhu6,7,8

  • 1Department of Clinlical Medicine, Weifang Medical College, Weifang, China.

Molecular Biology Reports
|November 23, 2021
PubMed
Abstract

Insights

Regenerating protein 3 alpha (REG3A) has varied roles in cancer. Understanding REG3A's complex functions may offer new therapeutic targets for cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • REG3A is a protein found in various tissues, typically absent in immune cells.
  • Its expression is influenced by injury, infection, inflammation, and cytokines, mediating tissue repair and immune responses.
  • Recent research highlights REG3A's emerging role in cancer biology.

Purpose of the Study:

  • To investigate the structure, expression, regulation, and function of REG3A.
  • To explore the potential role of REG3A in tumor development and progression.

Main Methods:

  • Comprehensive literature review.
  • Data synthesis and organization on REG3A's physiological and oncological functions.

Main Results:

  • REG3A exhibits contradictory roles in different cancer models.
  • High REG3A expression is linked to oncogenic effects in some cancers.
  • Conversely, decreased REG3A expression has been associated with suppressed tumor growth in other studies.

Conclusions:

  • REG3A's dual role in cancer necessitates further investigation.
  • A deeper understanding of REG3A could reveal novel therapeutic strategies for cancer treatment.
Keywords:
CancerGene expressionReceptorRegenerating protein REG3ARegulationSignaling pathway

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