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Tolerance of peritoneal and residual renal function to intraperitoneal gadolinium-based agents: An animal

Jing Dong1, Wenlu Li1, Jian Shu1

  • 1Department of Radiology, Affiliated Hospital of Southwest Medical University, Luzhou, China.

Seminars in Dialysis
|November 23, 2021
PubMed
Abstract

Insights

Magnetic resonance (MR) peritoneography is effective for detecting complications in continuous ambulatory peritoneal dialysis (CAPD) patients. This study found no significant impact on kidney function or image quality with varying gadolinium agent concentrations, suggesting lower doses may be safe.

Area of Science:

  • Radiology
  • Nephrology
  • Medical Imaging

Background:

  • Magnetic resonance (MR) peritoneography offers excellent soft-tissue contrast for evaluating continuous ambulatory peritoneal dialysis (CAPD)-related complications.
  • Optimal gadolinium-based agent concentrations and their effects on peritoneum and renal function in MR peritoneography remain unstudied.

Purpose of the Study:

  • To determine the optimal concentration of gadolinium-based agents for MR peritoneography.
  • To assess the side effects of gadolinium-based agents on peritoneal tissue and residual renal function.

Main Methods:

  • Uremic and normal rats underwent MR peritoneography after injection with varying concentrations of gadolinium-based agents mixed with peritoneal dialysate.
  • Peritoneal morphology was assessed via hematoxylin and eosin and Masson staining.
  • Residual renal function was evaluated using serum creatinine levels and kidney histopathology.

Main Results:

  • Gadolinium-based agents showed no significant adverse effects on residual renal function.
  • Image quality was consistent across different gadolinium-based agent concentrations.
  • Histological examination revealed no significant changes in peritoneal morphology or kidney pathology.

Conclusions:

  • Gadolinium-based agents at tested concentrations do not compromise residual renal function or image quality in MR peritoneography.
  • Based on previous concerns, reducing gadolinium dosage to the minimum effective level is recommended for MR peritoneography.

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