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[Sepsis Code: dodging mortality in a tertiary hospital].

R Méndez1, A Figuerola, M Chicot

  • 1Rosa Méndez Hernández. Servicio de Anestesia y Reanimación. Hospital Universitario de La Princesa. Calle Diego de León 62. 28006. Madrid, Spain. rosamen2004@hotmail.com.

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PubMed
Summary
This summary is machine-generated.

The Sepsis Code (CSP) implementation significantly reduced sepsis patient mortality from 24% to 15% between 2015 and 2018. Key factors predicting increased mortality include elevated lactate, creatinine, and the need for amines.

Keywords:
aminescreatininelactatemortalitysepsis code

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Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Health Services Research

Background:

  • Sepsis poses a significant global health challenge, necessitating early detection and treatment.
  • The Sepsis Code (CSP) initiative was implemented in 2015 to provide healthcare professionals with tools for managing sepsis.
  • Evaluating the impact of such interventions is crucial for improving patient outcomes.

Purpose of the Study:

  • To assess the effect of the Sepsis Code implementation on patient mortality.
  • To identify clinical and analytical variables associated with increased sepsis-related mortality.

Main Methods:

  • A retrospective analytical study was conducted on 1,121 patients with CSP alert activation from 2015 to 2018.
  • Data collected included clinical-epidemiological variables, laboratory parameters, and severity indicators (e.g., critical care unit admission, vasopressor use).
  • Statistical significance was determined using a p-value threshold of < 0.05.

Main Results:

  • Mortality demonstrated a significant linear decrease from 24% in 2015 to 15% in 2018.
  • 32% of patients required admission to a critical care unit, with an average length of stay of 16 days.
  • Predictive factors for mortality included lactate levels > 2 mmol/L, creatinine > 1.6 mg/dL, and the need for vasopressors.

Conclusions:

  • The implementation of the Sepsis Code effectively reduces mortality in patients with sepsis and septic shock.
  • Elevated lactate, creatinine, and the requirement for vasopressors within the first 24 hours are independently associated with increased mortality risk.