Related Experiment Video
Updated: Oct 12, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Substituent Effect in Pyridinium Alkynylanthracenes on their Performance as Photosensitizers for Photodynamic Therapy
Valentina Brega1, Samuel W Thomas1
1Department of Chemistry, Tufts University, Medford, Massachusetts.
Abstract:
Progress in photodynamic therapy (PDT) relies on the design and synthesis of photosensitizers that can efficiently sensitize singlet oxygen using visible light irradiation while displaying limited dark toxicity. Here, we highlight the paper by Linker and coworkers published in this issue of Photochemistry and Photobiology, which evaluates the effect of the regiochemistry of pyridinium rings in three isomeric pyridinium alkynylanthracenes on their performance as photosensitizers for PDT in HeLa cells.
Related Concept Videos
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Directing and Steric Effects in Disubstituted Benzene Derivatives
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Directing Effect of Substituents: ortho–para-Directing Groups
Basicity of Heterocyclic Aromatic Amines
Directing Effect of Substituents: meta-Directing Groups
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
