Free-breathing 3D cardiac T₁ mapping with transmit B₁ correction at 3T

To develop a cardiac T₁ mapping method for free-breathing 3D T₁ mapping of the whole heart at 3 T with transmit B₁ ( $$ ) correction.

A free-breathing, electrocardiogram-gated inversion-recovery sequence with spoiled gradient-echo readout was developed and optimized for cardiac T₁ mapping at 3 T. High-frame-rate dynamic images were reconstructed from sparse (k,t)-space data acquired along a stack-of-stars trajectory using a subspace-based method for accelerated imaging. Joint T₁ and flip-angle estimation was performed in T₁ mapping to improve its robustness to $$ inhomogeneity. Subject-specific timing of data acquisition was used in the estimation to account for natural heart-rate variations during the imaging experiment.

Simulations showed that accuracy and precision of T₁ mapping can be improved with joint T₁ and flip-angle estimation and optimized electrocardiogram-gated spoiled gradient echo-based inversion-recovery acquisition scheme. The phantom study showed good agreement between the T₁ maps from the proposed method and the reference method. Three-dimensional cardiac T₁ maps (40 slices) were obtained at a 1.9-mm in-plane and 4.5-mm through-plane spatial resolution from healthy subjects (n = 6) with an average imaging time of 14.2 ± 1.6 minutes (heartbeat rate: 64.2 ± 7.1 bpm), showing myocardial T₁ values comparable to those obtained from modified Look-Locker inversion recovery. The proposed method generated $$ maps with spatially smooth variation showing 21%-32% and 11%-15% variations across the septal-lateral and inferior-anterior regions of the myocardium in the left ventricle.

The proposed method allows free-breathing 3D T₁ mapping of the whole heart with transmit B₁ correction in a practical imaging time.