Pathogen Receptor Membrane-Coating Facet Structures Boost Nanomaterial Immune Escape and Antibacterial Performance

Nanomaterials show great potential for the treatment of bacterial infections, but their effects remain limited by low antibacterial efficiency and immune clearance. Facet-dependent nanozymes coated with pathogen receptor membranes were fabricated, providing an approach for producing superphotothermal antibacterial nanomaterials with high biocompatibility and low immune clearance. (100)- and (112)-Faceted CuFeSe₂ presented excellent photothermal conversion efficiency (46%). However, the peroxidase-like activity of (100)-faceted CuFeSe₂ enhanced the decomposition of H₂O₂ to hydroxyl radicals (^•OH) and was markedly greater than that of (112)-faceted CuFeSe₂, with nearly 100% of Staphylococcus aureus being killed under near-infrared (NIR) irradiation. Importantly, bacteria-pretreated immune membranes (i.e., pathogen receptor membranes) coated with CuFeSe₂ exhibited superior S. aureus-binding ability, presented obvious immune-evading capability, and resulted in targeted delivery to infected sites. As a proof-of-principle demonstration, these findings hold promise for the use of pathogen receptor membrane-coated facet-dependent nanomaterials in clinical applications and the treatment of bacterial infections.