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Human bronchial-pulmonary proteomics in coronavirus disease 2019 (COVID-19) pandemic: applications and implications

Heng Wee Tan1, Yan-Ming Xu1, Andy T Y Lau1

  • 1Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, People's Republic of China.

Expert Review of Proteomics
|November 23, 2021
PubMed
Abstract

Insights

Human bronchial-pulmonary proteomics is key to understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics and pathogenicity. This research aids in discovering biomarkers and therapeutic targets for coronavirus disease 2019 (COVID-19).

Area of Science:

  • Proteomics
  • COVID-19 Research
  • SARS-CoV-2 Pathogenesis

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), impacting multiple organs with the respiratory system as the primary infection site.
  • Understanding the molecular mechanisms of SARS-CoV-2 infection is critical for developing effective treatments.

Purpose of the Study:

  • To review the application of omics technologies in SARS-CoV-2 research.
  • To specifically examine current knowledge of COVID-19 through the lens of human bronchial-pulmonary proteomics.
  • To identify knowledge gaps addressable by proteomics in COVID-19 research.

Main Methods:

  • Review of existing literature on omics technologies and COVID-19.
  • Focus on human bronchial-pulmonary proteomics data and findings.
  • Analysis of knowledge gaps in the context of proteomic research.

Main Results:

  • Human bronchial-pulmonary proteomics provides crucial insights into SARS-CoV-2 dynamics, tropism, and pathogenicity.
  • Proteomics is vital for identifying potential biomarkers and therapeutic targets for COVID-19.
  • Current research highlights the importance of proteomic analysis in understanding host-pathogen interactions in the lungs.

Conclusions:

  • Human bronchial-pulmonary proteomics is essential for advancing COVID-19 understanding and therapeutic development.
  • Further multi-omics research on lungs and other organs is needed for a comprehensive understanding of COVID-19's impact.
Keywords:
COVID-19SARS-CoV-2affinity purificationlung diseasesmass spectrometrymicroarraymulti-omicsorganoidsproximity labelling

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