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Nutrition senolytics - illusion or reality for cognitive ageing?
Xi Chen1, Henry Brodaty1,2, Fiona O'Leary3
1Dementia Centre for Research Collaboration.
Current Opinion in Clinical Nutrition and Metabolic Care
|November 23, 2021
Summary
Nutritional senolytics show limited evidence for improving cognitive aging in older adults. Whole foods like berries, nuts, and specific diets show promise against cognitive decline.
Area of Science:
- Gerontology
- Nutritional Neuroscience
- Cellular Aging
Background:
- Cell senescence contributes to age-related diseases, including cognitive impairment.
- Senolytics, agents that clear senescent cells, are explored for anti-aging therapies.
- Nutritional approaches targeting senescence are investigated for cognitive health in aging.
Purpose of the Study:
- To review recent evidence (last 18 months) on nutritional senolytics and cognitive aging.
- To assess the impact of oral supplements and dietary patterns on cognitive health in older adults.
- To evaluate nutritional senolytic agents and senescence-associated secretory phenotype (SASP) suppressors for cognitive benefits.
Main Methods:
- Systematic review of 19 systematic reviews and 17 intervention studies.
- Focused on nutritional senolytics, SASP suppressors, and cognitive aging in older adults.
- Examined evidence for oral supplements, whole foods, and dietary patterns.
Main Results:
- No evidence found for oral nutritional senolytic supplements improving cognitive aging.
- Dietary patterns like the Mediterranean and MIND diets showed protective effects against cognitive decline.
- Berries and nuts were identified as potentially beneficial food sources.
Conclusions:
- Current evidence does not support oral supplements as nutritional senolytics for cognitive aging.
- Whole foods and healthy dietary patterns are crucial for anti-aging strategies and cognitive health.
- Further research is needed on the long-term effects and safety of nutritional senolytics.
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