Related Experiment Video
Updated: Jul 16, 2026
Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems
Published on: March 3, 2010
A novel imine-linked covalent organic framework for rapid detection of methyl paraoxon
Mengyao Li1, Lulu Guo1, Lili Chen1
1Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, Jiangxi Province, China. chenlaura0797@163.com.
Abstract:
Methyl paraoxon (MP) has attracted more and more attention in recent years because of its severe neurotoxicity and respiratory toxicity. Therefore, it is very urgent to develop new and sensitive MP detection methods for health protection and public safety. Covalent organic frameworks (COFs) are widely used in fluorescence detection because they can effectively transmit and amplify probe signals with multiple identical binding sites within an extended framework. Here, COFML-DHTA nanosheet material was synthesized by the solvothermal reaction of melem (ML) and 2,5-dihydroxyterephthalaldehyde (DHTA). The resulting COFML-DHTA exhibits remarkable luminescence quenching toward MP due to the relationship of competitive absorption and Förster resonance energy transfer between MP and COFML-DHTA. COFML-DHTA can be used for sensitive and selective detection of MP in a wide concentration range of 0.57 ng mL-1 to 30 μg mL-1 with a detection limit of 0.19 ng mL-1. The material has good chemical stability, excellent selectivity, good reusability and hydrophilicity, which provide more possibilities for COFs in the detection of pesticides.
Insights
A novel covalent organic framework (COF), COFML-DHTA, was developed for detecting methyl paraoxon (MP). This material offers a sensitive and selective method for identifying MP, crucial for public safety and health protection.
Area of Science:
- Materials Science
- Analytical Chemistry
- Environmental Science
Background:
- Methyl paraoxon (MP) poses significant neurotoxic and respiratory risks, necessitating sensitive detection methods.
- Covalent organic frameworks (COFs) are promising for fluorescence detection due to their signal amplification capabilities.
Purpose of the Study:
- To synthesize and characterize a novel COF material for sensitive and selective methyl paraoxon detection.
- To investigate the mechanism of fluorescence quenching for MP detection using the synthesized COF.
Main Methods:
- Solvothermal synthesis of COFML-DHTA from melem (ML) and 2,5-dihydroxyterephthalaldehyde (DHTA).
- Fluorescence spectroscopy was employed to evaluate the detection performance of COFML-DHTA towards MP.
- Analysis of competitive absorption and Förster resonance energy transfer (FRET) mechanisms.
Main Results:
- COFML-DHTA demonstrated significant luminescence quenching in the presence of MP.
- The material achieved sensitive and selective MP detection over a wide range (0.57 ng mL-1 to 30 μg mL-1) with a low detection limit (0.19 ng mL-1).
- COFML-DHTA exhibited good chemical stability, selectivity, reusability, and hydrophilicity.
Conclusions:
- COFML-DHTA is a highly effective fluorescent sensor for methyl paraoxon detection.
- The developed material shows potential for real-world applications in pesticide monitoring and public safety.
