Comparative effectiveness of immune system stimulators in calves' vaccination

The work aimed to study the comparative effectiveness of the immunostimulants "Roncoleukin" and propolis milk for increasing the nonspecific and specific resistance and immunological reactivity of calves during vaccination against salmonellosis. A study of the "Roncoleukin" effect combined with propolis milk on the biochemical, immunological, and serological parameters of calves during vaccination against salmonellosis was carried out. The objects of research were calves from birth to 2 months of age of the Simmental breed. According to the principle of analogs, they were divided into four groups (control and three experimental), six heads each. All animals at 10 days of age were vaccinated against salmonellosis. The animals of the first experimental group were injected subcutaneously with "Roncoleukin" at birth. Then "Roncoleukin" was injected during vaccination against salmonellosis. The calves of the second experimental group were drunk with propolis milk before feeding. The animals of the third experimental group were drunk with propolis milk before feeding; "Roncoleukin" was injected during vaccination. The use of "Roncoleukin" and propolis milk contributes to correcting immunological parameters and the protein spectrum of the blood during vaccination. The most pronounced changes are observed in calves of the first and third experimental groups. "Roncoleukin" and propolis milk contribute to forming an active specific immune response in calves during vaccination against salmonellosis, which is expressed in an increase in the titer of anti-salmonella antibodies. The maximum antibody titer level was established in calves of the first and third experimental groups, three times higher than the control value.