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Nonobstructive pyelonephritis initially seen as acute renal failure.

S N Adler

    Archives of Internal Medicine
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Severe pyelonephritis can present with elevated liver enzymes, positive cultures, and acute kidney injury. Bilateral medullary necrosis was confirmed, aiding prompt diagnosis in this case.

    Area of Science:

    • Nephrology
    • Infectious Diseases
    • Clinical Pathology

    Background:

    • Severe pyelonephritis is a serious kidney infection.
    • Early diagnosis and treatment are crucial to prevent complications.
    • Renal function can be significantly impacted by severe infections.

    Observation:

    • A patient presented with a triad of symptoms: elevated serum glutamic-oxaloacetic transaminase (SGOT) and lactic dehydrogenase (LDH) levels.
    • Positive blood and urine cultures indicated a systemic infection.
    • The patient also exhibited signs of acute renal failure.

    Findings:

    • Renal biopsy and postmortem examination revealed bilateral medullary necrosis.
    • This histological finding is a severe consequence of the pyelonephritis.

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  • The combination of clinical and laboratory findings pointed towards this specific pathology.

    • Implications:

    • Recognizing this specific triad can aid in the prompt antemortem diagnosis of severe pyelonephritis with medullary necrosis.
    • This case highlights the importance of correlating clinical presentation with laboratory and pathological findings.
    • Understanding these associations can guide clinical management and improve patient outcomes in similar cases.