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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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Defining the decision problem: a scoping review of economic evaluations for Clostridioides difficile interventions
M Richardson1, A Erman1, N Daneman1
1Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
The Journal of Hospital Infection
|November 23, 2021
Summary
Economic evaluations for Clostridioides difficile infection often assess narrow decision problems. This limited scope may impact optimal healthcare resource allocation for preventing and treating this infection.
Area of Science:
- Health Economics
- Infectious Disease Epidemiology
- Healthcare Management
Background:
- Clostridioides difficile infection (CDI) is a primary cause of hospital-acquired infectious diarrhea.
- Existing CDI interventions are often evaluated independently, not holistically within the care pathway.
Purpose of the Study:
- To analyze the scope of decision problems in economic evaluations of Clostridioides difficile interventions.
- To understand how CDI interventions are framed in cost-effectiveness and cost-utility analyses.
Main Methods:
- A scoping review following the Joanna Briggs Institute framework was performed.
- Literature search focused on Clostridioides difficile and economic evaluations.
- Studies were categorized based on the number of interventions and care pathway domains assessed.
Main Results:
- Out of 46 in-depth analyzed studies, 93% (43/46) focused on a single intervention.
- Only 7% (3/46) of studies considered multiple interventions, either bundled or sequential.
- No studies evaluated multiple interventions across both prevention and treatment domains.
Conclusions:
- Economic evaluations for CDI interventions typically address narrowly defined decision problems.
- This limited scope may hinder optimal resource allocation for CDI prevention and treatment strategies.
Keywords:
Clostridioides difficile infectionEconomic evaluationHealth technology assessmentPreventionScoping reviewMore Related Videos
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