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Related Experiment Video

Updated: Oct 12, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

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Published on: September 22, 2017

Chronic recurrent multifocal osteomyelitis causing optic neuropathy.

Joel Mudri¹, Jane Lock², Omkar Phadke³

¹Department of Ophthalmology, Royal Perth Hospital, Perth WA Australia.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus

|November 23, 2021

Summary

This summary is machine-generated.

Chronic recurrent multifocal osteomyelitis (CRMO) can affect the orbit and facial bones, potentially causing optic neuropathy. Early diagnosis and treatment are crucial to prevent permanent vision loss in pediatric patients.

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Published on: August 21, 2017

Area of Science:

Ophthalmology
Pediatric Rheumatology
Osteomyelitis Research

Background:

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone disease typically affecting long bones, but can present with extra-skeletal manifestations.
Orbital and facial bone involvement in CRMO is uncommon, posing diagnostic challenges and risks for adjacent structures like the optic nerve.

Observation:

An 8-year-old girl with a history of CRMO presented with recurrent periorbital swelling and symptoms of left optic neuropathy.
Initial presentation was delayed, leading to significant visual impairment in the left eye.

Findings:

The patient's CRMO involved the orbit and facial bones, causing optic nerve damage (optic neuropathy).
Treatment with adalimumab showed a positive response in managing the inflammatory bone disease.
Despite treatment, the delayed presentation resulted in irreversible unilateral optic nerve atrophy and reduced visual acuity.

Implications:

Orbital inflammatory disease is a rare but serious manifestation of CRMO that requires prompt recognition.
Early diagnosis and intervention in pediatric CRMO involving the orbit are critical to prevent permanent vision loss.
This case highlights the importance of considering CRMO in the differential diagnosis of pediatric orbital inflammatory conditions.