[Molecularly imprinted sorbent for biological fluids sample preparation in forensic toxicology]

The objective of this work is to evaluate the possibility of biological fluids sample preparation in forensic toxicology using a molecularly imprinted sorbent based on acrylic acid derivatives. Phenylpiracetam has similar physicochemical properties to those of pyrrolidinophenone derivatives and reproduces their behavior during solid-phase extraction. The phenylpiracetam recovery from blood and urine model samples is 75% for concentration range of 100.0-6000.0 ng/ml. The accuracy of phenylpiracetam extraction does not exceed ±12% for blood samples and ±6% for urine samples. The repeatability is no more than 16% and 13% for blood and urine samples, respectively. A study of the cross-reactivity of the molecularly imprinted sorbent with some drugs showed the selectivity of the sample preparation procedure.