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Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
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Inhibition of Cdk Activity02:34

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Positive Regulator Molecules02:39

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Centrosome Duplication02:25

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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
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Anaphase Promoting Complex00:50

Anaphase Promoting Complex

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The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
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Updated: Oct 12, 2025

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
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Three decades of Cdk5.

Ping-Chieh Pao1,2, Li-Huei Tsai3,4

  • 1Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Journal of Biomedical Science
|November 24, 2021
PubMed
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Cyclin-dependent kinase 5 (Cdk5) is crucial for brain function. Aberrant Cdk5 activity is linked to neurodegenerative diseases, highlighting its importance in neuronal health.

Keywords:
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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Cyclin-dependent kinase 5 (Cdk5) is a key regulator of neuronal processes.
  • Dysregulation of Cdk5 disrupts normal brain function.
  • Cdk5's roles and regulation have been studied for decades.

Purpose of the Study:

  • To review the discovery and regulation of Cdk5.
  • To highlight Cdk5's diverse functions in neuronal and non-neuronal systems.
  • To discuss Cdk5's involvement in neurodegenerative diseases.

Main Methods:

  • Literature review of Cdk5 research.
  • Synthesis of findings on Cdk5 modulation and action.
  • Analysis of Cdk5's role in physiological and pathological conditions.

Main Results:

  • Cdk5 regulates neuronal/synaptic functions, circadian clocks, DNA damage, cell cycle, and mitochondrial function.
  • Cdk5 exhibits non-neuronal functions.
  • Aberrant Cdk5 activity is a common factor in neurodegenerative diseases.

Conclusions:

  • Cdk5 plays a critical role in maintaining brain function.
  • Understanding Cdk5 regulation and function is vital for addressing neurodegeneration.
  • Further research into Cdk5 pathways may offer therapeutic strategies.