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Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
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Transcriptome sequencing identified the ceRNA network associated with recurrent spontaneous abortion.

Yong Huang1, Jiayuan Hao1, Yuan Liao1

  • 1Department of Reproductive Medicine, The Second Affiliated Hospital of Hainan Medical University, No. 368, Yehai Avenue, Haikou, 570311, Hainan, People's Republic of China.

BMC Medical Genomics
|November 24, 2021
PubMed
Summary
This summary is machine-generated.

This study identified a novel network of long non-coding RNAs, microRNAs, and messenger RNAs involved in recurrent spontaneous abortion (RSA). The findings offer a theoretical basis for understanding RSA mechanisms and potential therapeutic targets.

Keywords:
Recurrent spontaneous abortionTranscriptome sequencingceRNA networklncRNA

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Area of Science:

  • Reproductive Biology
  • Genomics
  • Molecular Biology

Background:

  • Recurrent spontaneous abortion (RSA) is a significant pregnancy complication with substantial patient burden.
  • Understanding the molecular underpinnings of RSA is crucial for developing effective management strategies.

Purpose of the Study:

  • To explore the long non-coding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory network associated with recurrent spontaneous abortion.
  • To identify key molecular players and pathways involved in the pathogenesis of RSA.

Main Methods:

  • Transcriptome sequencing of villus tissue from RSA patients and normal abortion controls.
  • Identification and analysis of differentially expressed lncRNAs, miRNAs, and mRNAs (DELs, DEMs, DEGs).
  • Functional enrichment analysis (GO, KEGG) and construction of a lncRNA-related competing endogenous RNA (ceRNA) network using Cytoscape.

Main Results:

  • 1008 DELs, 475 DEGs, and 37 DEMs were identified between RSA and normal samples.
  • A novel lncRNA-related ceRNA network was constructed, comprising 31 lncRNAs, hsa-miR-210-5p, and three mRNAs: NTNG2, GRIA1, and AQP1.
  • Functional analysis revealed potential roles of these molecules in RSA pathogenesis.

Conclusions:

  • A complex lncRNA-miRNA-mRNA network, centered around hsa-miR-210-5p, NTNG2, GRIA1, and AQP1, is implicated in recurrent spontaneous abortion.
  • This network provides a theoretical foundation for further research into RSA mechanisms.
  • The identified molecular players may serve as potential biomarkers or therapeutic targets for RSA.