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Related Concept Videos

Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
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Antibody Structure01:10

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Defense Against Bacterial Pathogens01:31

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Communication is key: Innate immune cells regulate host protection to helminths.

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Updated: Oct 12, 2025

Basophil Activation Test for Allergy Diagnosis
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Basophils in antihelminth immunity.

Jianya Peng1, Mark C Siracusa1

  • 1Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.

Seminars in Immunology
|November 24, 2021
PubMed
Summary

Basophils, often linked to helminth infections, have diverse roles beyond promoting immunity. Recent studies reveal they can also restrict inflammation and interact with the nervous system, transforming our understanding of their function.

Keywords:
Antihelminth immunityBasophilsHelminthsNeuro-immune crosstalkTh2

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Area of Science:

  • Immunology
  • Parasitology
  • Neuroimmunology

Background:

  • Basophilia is a hallmark of helminth infections.
  • Basophils were thought to primarily promote anti-helminth immunity via type 2 T helper (Th2) cell responses by secreting IL-4 and other type 2 cytokines.

Purpose of the Study:

  • To review current basophil biology in the context of helminth infections.
  • To describe how recent studies are reshaping the understanding of basophil functions during helminth infections.

Main Methods:

  • Review of current literature on basophil functions in helminth infections.
  • Analysis of emerging studies on parasite-specific basophil effector functions.
  • Examination of data on basophil-mediated tissue protection and neuro-immune interactions.

Main Results:

  • Basophil functions in helminth infections are diverse and parasite-specific.
  • Basophils can restrict type 2 inflammation, preserving tissue integrity.
  • Basophils participate in neuro-immune interactions to regulate inflammation.

Conclusions:

  • The role of basophils in helminth infections is more complex than previously understood.
  • Emerging research highlights novel functions of basophils in immunity, tissue homeostasis, and neuro-immune communication.