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Related Experiment Video

Updated: Oct 12, 2025

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

Immune ageing at single-cell resolution.

Denis A Mogilenko¹, Irina Shchukina¹, Maxim N Artyomov²

¹Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.

Nature Reviews. Immunology

|November 24, 2021

Summary

This summary is machine-generated.

Immune system ageing causes increased disease susceptibility. Recent single-cell studies reveal detailed age-related changes in immune cells and tissues, offering new insights into immune ageing.

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Area of Science:

Immunology
Gerontology

Background:

Ageing significantly alters immune system function, increasing vulnerability to diseases.
Single-cell technologies have revolutionized the study of immune ageing.

Purpose of the Study:

To review recent single-cell studies on immune system ageing.
To detail age-related changes in immune cells, repertoires, and microenvironments.
To integrate findings from mouse and human studies.

Main Methods:

Unbiased single-cell profiling techniques.
Analysis of innate and adaptive immune cell populations.
Examination of antigen receptor repertoires and peripheral tissue microenvironments.

Main Results:

Comprehensive data reveal age-associated alterations across various immune components.
New insights complement established concepts of immune ageing.
Multidimensional data from mouse and human studies are presented.

Conclusions:

Single-cell resolution provides a detailed understanding of immune ageing.
Further research using advanced techniques is needed to address outstanding questions in immune ageing.