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Echocardiographic changes in elderly patients with heart failure with reduced ejection fraction after

Wei Gu1, Chuangye Xu2, Zhao Li1

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.

Cardiovascular Diagnosis and Therapy
|November 24, 2021
PubMed

Insights

Sacubitril-Valsartan significantly improved cardiac structure and function in elderly patients with heart failure with reduced ejection fraction (HFrEF) over six months. Key indicators like left ventricular ejection fraction (LVEF) improved, while chamber dimensions and mass decreased.

Area of Science:

  • Cardiology
  • Pharmacology
  • Geriatrics

Background:

  • Heart failure with reduced ejection fraction (HFrEF) significantly impacts elderly patients' cardiac structure and function.
  • Understanding the therapeutic effects of Sacubitril-Valsartan in this demographic is crucial for clinical practice.

Purpose of the Study:

  • To evaluate the changes in cardiac structure and function in elderly HFrEF patients after 6 months of Sacubitril-Valsartan treatment.
  • To assess the drug's efficacy on key echocardiographic parameters in a real-world clinical setting.

Main Methods:

  • A retrospective cohort study involving 336 elderly HFrEF patients hospitalized between May 2019 and May 2020.
  • Echocardiography was used to assess cardiac structure and function, focusing on left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left atrial diameter (LAD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), and left ventricular mass index (LVMI).
  • Outcomes were measured at baseline and after 6 months of Sacubitril-Valsartan therapy.

Main Results:

  • Sacubitril-Valsartan treatment led to a significant improvement in LVEF (39.07% to 48.49%, P<0.01).
  • The treatment resulted in significant reductions in LVEDD (59.97 mm to 54.70 mm, P<0.01), LVESD (47.59 mm to 40.59 mm, P<0.01), LAD (52.45 mm to 48.59 mm, P<0.01), and LVMI (125.20 g/m² to 105.16 g/m², P<0.01).
  • Improvements were consistent across subgroups, including those diagnosed with HFrEF on admission and patients in NYHA classes II and III.

Conclusions:

  • Sacubitril-Valsartan demonstrates significant efficacy in improving cardiac structure and function in elderly patients with HFrEF.
  • The findings support the use of Sacubitril-Valsartan as a therapeutic option for this patient population.
Abstract

Keywords:
Sacubitril-valsartancardiac functioncardiac structureechocardiographic changeheart failure with reduced ejection fraction (HFrEF)

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