[Effect of reinnervation on the state of transplanted kidneys in dogs]

In the experiments lasted for 2 years, the effect of surgical reinnervation on the morphofunctional state of autotransplanted and denervated kidney was studied in 175 dogs. General morphological, impregnational, special neurohistological investigations and kidney scanning demonstrated that 2 months after surgical reinnervation of the autotransplantated and denervated kidneys, active sprouting of nerve fibers, adrenergic and cholinergic including, was started along the degenerated nerve trunks, and by the 4th month the nerve fibers reached the renal glomeruli, tubules and pelves. A rather complete restoration of the organic innervation resembling that of the intact organ provided stability of the general morphological structure in the reinnervated kidney, its functional ability and prevented atrophy, sclerosis and stable functional depression observed in cases of renal transplantation and denervation without surgical reinnervation. From this point of view, the problem of necessary active surgical reinnervation of the renal transplantation is discussed.