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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Homocysteine as a Predictor Tool in Multiple Sclerosis.

Radu Razvan Mititelu1, Carmen Valeria Albu2, Manuela Violeta Bacanoiu3

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Discoveries (Craiova, Romania)
|November 24, 2021
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Summary

Elevated homocysteine levels in the blood are linked to worsening multiple sclerosis (MS) progression. The homocysteine to cobalamin ratio (HCR) may serve as a non-invasive marker for disease severity in MS patients.

Keywords:
cobalamin.homocysteinemultiple sclerosisvitamin status

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Area of Science:

  • Neurology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Multiple sclerosis (MS) is a progressive central nervous system disease with unknown causes.
  • Identifying reliable markers for MS progression is crucial for patient management.
  • Current markers may be invasive or lack specificity for disease severity.

Purpose of the Study:

  • To investigate homocysteine patterns as predictors of multiple sclerosis (MS) disease progression.
  • To identify a non-invasive marker for predicting MS outcomes and disease severity.
  • To analyze plasma homocysteine, cobalamin, and folate levels in different MS patient groups.

Main Methods:

  • Plasma homocysteine levels were measured using automated latex enhanced immunoassay.
  • Cobalamin and folate levels were determined via automated chemiluminescence immunoassay (CLIA).
  • Homocysteine to cobalamin ratio (HCR) was calculated for disease severity assessment.

Main Results:

  • Homocysteine plasma levels were significantly elevated in both relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients compared to controls.
  • SPMS patients exhibited significantly higher homocysteine concentrations than RRMS patients.
  • The HCR was significantly increased in the SPMS group, indicating a strong correlation with disease severity.

Conclusions:

  • Elevated plasma homocysteine is associated with multiple sclerosis.
  • The homocysteine to cobalamin ratio (HCR) shows potential as a non-invasive and effective biomarker for MS disease severity.
  • This study highlights the utility of homocysteine and HCR in understanding and potentially monitoring MS progression.