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Focusing Treatment on Pregnant Women With COVID Disease
Alina-Raluca Emanoil1, Emanuela Stochino Loi1, Anis Feki1
1Department of Gynecology and Obstetrics, Fribourg Cantonal Hospital, Fribourg, Switzerland.
Insights
This review prioritizes COVID-19 treatments and vaccines for pregnant women, offering dose-response and toxicity data. It highlights promising vaccine trial results for preventing SARS-CoV-2 infection during pregnancy.
Area of Science:
- Medical Research
- Infectious Diseases
- Maternal Health
Background:
- The COVID-19 pandemic poses significant risks to maternal and fetal health.
- Optimal management strategies for pregnant women with COVID-19 are lacking.
- Guidance for multidisciplinary teams on maternal-fetal treatment and delivery timing is limited.
Purpose of the Study:
- To review and prioritize potential COVID-19 treatments and vaccines for pregnant women.
- To provide dose-response and dose-toxicity information for investigational drugs.
- To summarize current evidence on COVID-19 vaccine efficacy and safety in pregnancy.
Main Methods:
- Comprehensive literature evaluation of drugs and vaccines for COVID-19.
- Prioritization of potential treatments based on efficacy and safety data.
- Analysis of available trial data, including small studies on pregnant populations.
Main Results:
- Several drugs and vaccines are under investigation for COVID-19 treatment and prevention.
- Dose-response and dose-toxicity information has been compiled for evaluated drugs.
- Early trial data on COVID-19 vaccines in pregnant individuals is largely positive, showing reassuring results.
Conclusions:
- Evidence supports the investigation of specific treatments and vaccines for COVID-19 in pregnant women.
- Vaccine data, though limited, indicates a positive safety and efficacy profile for preventing SARS-CoV-2 infection during pregnancy.
- Further research is needed to establish definitive management guidelines for COVID-19 in this vulnerable population.
Abstract:
Since the emergence of a novel coronavirus in China at the end of December 2019, its infection - COVID-19 - has been associated with high morbidity and mortality and has left healthcare systems wrestling with the optimal management strategy, especially for vulnerable populations, such as pregnant women. At this moment, few resources exist to guide the multi-disciplinary team through decisions regarding optimal maternal-fetal treatment and delivery timing. In this article, we present the drugs and vaccines under investigation as potential treatments and prevention for COVID-19 infection. Based on a comprehensive evaluation, we prioritized these possible treatments, and provide dose-response and dose-toxicity information on each drug. Currently, there is limited but very increasing reassuring information concerning vaccines to prevent SARS-CoV-2 during pregnancy, and in this review, we also emphasize the results (mostly positive) provided by the few small trials evaluating COVID-19 vaccines in pregnant patients.
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