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Updated: Oct 12, 2025

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Published on: February 14, 2018
Ketoconazole beyond antifungal activity: Bioinformatics-based hypothesis on lipid metabolism in dandruff and
Vinicius Goularte-Silva1, Luciana Campos Paulino1
1Center for Natural Sciences and Humanities, Federal University of ABC, Santo André, Brazil.
Abstract:
The role of Malassezia yeasts in dandruff and seborrheic dermatitis is unclear; however, antifungal therapy with ketoconazole is commonly used. We propose that ketoconazole shifts skin lipid profile, affects Malassezia lipid metabolism and favours biotin-producing bacteria. Biotin regulates inflammatory response and cell proliferation, contributing to symptom improvement.
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