Related Experiment Video
Updated: Oct 12, 2025
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Threading of three rings on two stations: a convergent approach to [4]rotaxane
Yidan Zhou1, Jinyang Wu1, Zejiang Liu1
1College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China. lhyuan@scu.edu.cn.
Abstract:
A novel approach to efficient and selective construction of [4]rotaxane was proposed to demonstrate the superiority of H-bonded azo-macrocycles in forging higher order rotaxanes. The single crystal structure reveals the importance of the interplay of multiple non-covalent bonding interactions, particularly π-stacking interactions, in stabilizing the host-guest complex. This may open an avenue to the synthesis of oligomeric mechanically interlocked molecules containing fewer stations but more rings.
More Related Videos
06:56Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions
Published on: October 10, 2013
08:00Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
Published on: November 25, 2011
Related Concept Videos
Chair Conformation of Cyclohexane
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)
Thermal Electrocyclic Reactions: Stereochemistry
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
Stereoisomerism of Cyclic Compounds
Deformation in a Circular Shaft
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction