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Published on: November 9, 2019
Pd-catalyzed bidentate auxiliary assisted remote C(sp3)-H functionalization
Kangkan Talukdar1, Tariq A Shah2, Tanumay Sarkar1
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India. tpunni@iitg.ac.in.
Abstract:
Pd-catalyzed C-H functionalisation affords effective synthetic tools to construct C-C and C-X bonds. Despite the challenges, the distal functionalization of C(sp3)-H bonds has witnessed significant developments and the use of bidentate auxiliaries has garnished this area by providing an opportunity to control reactivity as well as selectivity beyond proximal sites. This article covers the recent developments on the Pd-catalyzed bidentate auxiliary-assisted distal C(sp3)-H functionalization and is categorized based on the nature of functionalizations.
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