Transition metal catalysed direct construction of 2-pyridone scaffolds through C-H bond functionalizations
Subarna Pan1, Souradip Sarkar1, Bidhan Ghosh1
1Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. rsamanta@chem.iitkgp.ac.in.
Abstract:
Substituted 2-pyridone is one of the most frequent scaffolds among nitrogen-containing bioactive natural products, pharmaceuticals and organic materials. Besides the classical syntheses to construct this class of molecules, retrosynthetically more straightforward approaches based on transition metal catalysed C-H bond functionalizations have been explored recently. In this review, we have summarized the recent progress in the direct transition metal catalysed construction of substituted 2-pyridone scaffolds via site-selective C-H bond functionalizations.
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