CH Activation of Cationic Bismuth Amides: Heteroaromaticity, Derivatization, and Lewis Acidity

Cationization of Bi(NPh₂)₃ has recently been reported to allow access to single- and double-CH activation reactions, followed by selective transformation of Bi-C into C-X functional groups (X = electrophile). Here we show that this approach can successfully be transferred to a range of bismuth amides with two aryl groups at the nitrogen, Bi(NR^aryl₂)₃. Exchange of one nitrogen-bound aryl group for an alkyl substituent gave the first example of a homoleptic bismuth amide with a mixed aryl/alkyl substitution pattern at the nitrogen, Bi(NPhiPr)₃. This compound is susceptible to selective N-N radical coupling in its neutral form and also undergoes selective CH activation when transformed into a cationic species. The second CH activation is blocked due to the absence of a second aryl moiety at nitrogen. The Lewis acidity of neutral bismuth amides is compared with that of cationic species "[Bi(aryl)(amide)(L)]⁺" and "[Bi(aryl)₂(L)]⁺" based on the (modified) Gutmann-Beckett method (L = tetrahydrofuran or pyridine). The heteroaromatic character of [Bi(C₆H₃R)₂NH(triflate)] compounds, which are iso-valence-electronic with anthracene, is investigated by theoretical methods. Analytical methods used in this work include nuclear magnetic resonance spectroscopy, single-crystal X-ray diffraction, mass spectrometry, and density functional theory calculations.