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Updated: Oct 12, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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Sequential Knoevenagel [4+1] Cycloaddition-Condensation-Aza-Friedel-Crafts Intramolecular Cyclization: A

Nathan Bedard1, Christopher Foley1, Garrett J Davis1

  • 1Department of Chemistry & Biochemistry, College of Science, The University of Arizona, Tucson, Arizona 85721, United States.

The Journal of Organic Chemistry
|November 24, 2021
PubMed
Summary

This study introduces a new two-step method to create tunable fluorescent tetracyclic indolizines. The novel protocol uses a multicomponent reaction and in situ oxidation for efficient synthesis of these novel compounds.

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