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Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial.

Amir Hadanny1,2,3,4, Relly Forer5, Dina Volodarsky5

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Aging
|November 24, 2021
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Summary
This summary is machine-generated.

Hyperbaric oxygen therapy (HBOT) significantly altered gene expression in healthy older adults, impacting 1912 genes. This study shows HBOT influences the transcriptome in normal aging, offering new insights into aging processes.

Keywords:
HBOTRNAaginghyperbaric oxygentranscriptome

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Area of Science:

  • Gerontology
  • Molecular Biology
  • Biomedical Engineering

Background:

  • Aging is a natural process involving physiological decline and increased susceptibility to age-related diseases.
  • Changes in gene expression are key drivers of cellular aging and disease risk.
  • Hyperbaric oxygen therapy (HBOT) is a treatment involving exposure to oxygen at higher than atmospheric pressure.

Purpose of the Study:

  • To investigate the effects of HBOT on gene expression in healthy, non-pathological aging adults.
  • To determine if HBOT can modulate molecular pathways associated with aging.

Main Methods:

  • Thirty-five healthy adults aged 64+ received 60 daily HBOT sessions.
  • Whole blood samples were collected at multiple time points: baseline, during HBOT, and post-treatment.
  • Differential gene expression analysis was conducted to identify changes.

Main Results:

  • HBOT induced significant changes in gene expression, with 1342 genes upregulated and 570 downregulated (p < 0.01 FDR) after 60 sessions.
  • Five genes, including ABCA13, showed significant downregulation (>1.5-fold change) post-HBOT.
  • ABCA13 expression remained significantly downregulated up to two weeks after the final HBOT session.

Conclusions:

  • This study provides the first human evidence that HBOT impacts the transcriptome in whole blood.
  • HBOT demonstrably alters gene expression patterns in a normal aging population.
  • These findings suggest HBOT may influence molecular mechanisms underlying the aging process.