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Tachykinin antagonist I: Specific, competitive and tissue-selective neurokinin B antagonists on contractile activity
T Hashimoto1, Y Uchida, S Naminohira
1School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Japanese Journal of Pharmacology
|December 1, 1987
Abstract:
Two neurokinin B (NKB) analogs, [Gly6]-NKB [3-10] and [Arg3, D-Ala6]-NKB [3-10], were tested for agonistic activity as well as for their ability to antagonize the myotropic actions of NKB, neurokinin A, substance P, physalaemin and eledoisin in isolated guinea-pig ileum, guinea-pig urinary bladder, rat duodenum, rat vas deferens and rat portal vein. [Gly6]-NKB [3-10] in the guinea-pig ileum and rat portal vein and [Arg3, D-Ala6]-NKB [3-10] in the guinea-pig ileum were found to be the first specific and competitive antagonists against NKB.