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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Silica covered stannic oxide nanoparticles-an easily prepared robust substrate for optical sensors
Yuan Chen1, Tianyu Ren1, Sarah Bramlitt1
1Chemistry Department, College of Engineering and Physical Sciences, University of New Hampshire, Durham, NH 03824, United States of America.
Abstract:
This paper describes a facile way to prepare a photophysically inert sensor substrate. Stannic oxide encapsulated silica nanoparticles with average diameters between 30 and 70 nm have been prepared by one-pot reverse-phase emulsion methodology. The constituents and core/shell morphology of the nanoparticles were demonstrated by electron microscopic technology, energy-dispersive x-ray spectroscopy, and x-ray photoelectron spectroscopy. X-ray diffraction was employed to provide additional constitutional and structural information. It has been shown that nanoparticles prepared by this method are optically clear in suspension. After anchoring optical indicators, this nanoparticle can be utilized as a sensor module both in biology and other analytical areas.

