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Related Experiment Video

Updated: Oct 12, 2025

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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The Correlation Between Body Weight and Intraocular Pressure.

Shawn Khan, Abirami Kirubarajan, Michael Lee

    Aerospace Medicine and Human Performance
    |November 25, 2021
    PubMed
    Summary

    Higher body mass index (BMI) is linked to increased intraocular pressure (IOP). Weight loss, such as through bariatric surgery, significantly reduces IOP, suggesting body weight impacts eye pressure.

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    Area of Science:

    • Ophthalmology
    • Aerospace Medicine
    • Metabolic Health

    Background:

    • Preflight body weight is a key factor in spaceflight-induced visual impairment.
    • Understanding the terrestrial relationship between body weight and intraocular pressure (IOP) is crucial for predicting and mitigating these changes.

    Purpose of the Study:

    • To systematically review and analyze the association between body mass index (BMI) and obesity indices with intraocular pressure (IOP).
    • To investigate the impact of weight changes, including bariatric surgery, on IOP.

    Main Methods:

    • A systematic review of studies was conducted using EMBASE, MEDLINE, and CENTRAL databases.
    • Data extraction and study selection were performed in duplicate for 1364 eligible titles and abstracts.
    • 39 studies were included for quantitative analysis, examining BMI and IOP parameters.

    Main Results:

    • A pooled analysis of 39 studies revealed a positive correlation between BMI and IOP.
    • Each unit increase in BMI was associated with a 6% increased likelihood of elevated IOP (pooled RR = 1.06).
    • Two studies on bariatric surgery demonstrated significant IOP reductions post-procedure.

    Conclusions:

    • Elevated BMI is associated with increased intraocular pressure in ground-based studies.
    • Weight loss interventions, like bariatric surgery, effectively decrease IOP.
    • Body weight significantly influences intraocular pressure, with implications for both clinical practice and spaceflight-related visual changes.